Recently, we have seen the emergence of the international laboratory in scientific research. These laboratories, characterized by internationally distributed members working to accomplish a unified goal, provide advantages such as cost savings and access to facilities and equipment. However, maintaining responsible conduct of research (RCR) in an international laboratory is complicated by the requirement for technology-mediated communication, lack of trust between local and distant group members, and cultural heterogeneity among lab members. Here we discuss issues we experienced while working in a international laboratory as part of the Singapore-M.I.T. Alliance for Research and Technology, and from our experience, we propose guidelines to maintain RCR in an international laboratory. With proper oversight and cognizance of RCR, work in an international laboratory harbors great benefit for scientists and provides unique opportunity to exchange ideas, data, and insight with scientists of distinct cultural background
