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The Importance of the Preservation of the Ethical Principle of Equipoise in the Design of Clinical Trials: Relative Impact of the Methodological Quality Domains on the Treatment Effect in Randomized Controlled Trials

Authors: Djulbegovic, Benjamin ; Cantor, Alan ; Clarke, Mike
Publication Type: Journal Article
Secondary Title: Accountability in Research: Policies & Quality Assurance
Abstract: Previous research has identified methodological problems in the design and conduct of randomized trials that could, if left unaddressed, lead to biased results. In this report the authors the problem of inadequate control interventi...
Year: 2003
DOI: 10.1080/08989620390267092

Biblio - KBL781 - 2011-01-25 17:45

Suppression, Bias, and Selection in Science: The Case of Cancer Research

Authors: Hess, David J.
Publication Type: Journal Article
Secondary Title: Accountability in Research: Policies & Quality Assurance
Abstract: Examines the suppression and bias in the role of bacterial agents in cancer etiology. Suppression of the bacterial research tradition; Suppression incidents in the United States during the decades following World War II; Two forms o...
Year: 1999
DOI: 10.1080/08989629908573932

Biblio - KBL781 - 2011-01-25 17:55

Financial Interests and Research Bias

Authors: Resnik, David B.
Publication Type: Journal Article
Secondary Title: Perspectives on Science
Abstract: Concern is rising among scientists, government officials and science policy experts about the increasing role of financial interests in research. Many believe that these interests are undermining research by causing bias and error, ...
Year: 2000
DOI: 10.1162/106361400750340497

Biblio - KBL781 - 2011-12-06 10:56

Evaluating solutions to sponsorship bias

Authors: Sismondo, S ; Doucet, M
Publication Type: Journal Article
Secondary Title: Journal of Medical Ethics
Abstract: Three proposed remedies to this problem are widely agreed upon among those concerned with the level of sponsorship bias: financial disclosure, reporting standards and trial registries. This paper argues that all of these remedies ei...
Year: 2008
DOI: 10.1136/jme.2007.022467

Biblio - KBL781 - 2011-12-06 10:50

Those Who Have the Gold Make the Evidence: How the Pharmaceutical Industry Biases the Outcomes of Clinical Trials of Medications

Authors: Lexchin, Joel
Publication Type: Journal Article
Secondary Title: Science and Engineering Ethics
Abstract: Pharmaceutical companies fund the bulk of clinical research that is carried out on medications. Poor outcomes from these studies can have negative effects on sales of medicines. Previous research has shown that company funded resear...
Year: 2012
DOI: 10.1007/s11948-011-9265-3

Biblio - KBL781 - 2012-07-09 11:26