The effect of scientific misconduct on the results of clinical trials: A Delphi survey

TitleThe effect of scientific misconduct on the results of clinical trials: A Delphi survey
Publication TypeJournal Article
Year of Publication2005
AuthorsAl-Marzouki, S, Roberts, I, Marshall, T, Evans, S
JournalContemporary Clinical Trials
Volume26
Issue3
Pagination331-337
Type of ArticleArticle
Publication Languageeng
ISSN Number15517144
Accession Number18106423
KeywordsClinical , DELPHI , Human , MEDICINE , Misconduct , Scientific
AbstractIn order to discover what types of scientific misconduct are most likely to influence the results of a clinical trial, the authors conducted a Delphi survey of expert opinion with three rounds of consultation. The study identified thirteen forms of scientific misconduct for which there was majority agreement (>50%) that they would be likely or very likely to distort the results and majority agreement (>50%) that they would be likely or very likely to occur. Of these, the over-interpretation of ‘significant’ findings in small trials, selective reporting and inappropriate subgroup analyses were the main themes. According to this expert group, the most important forms of scientific misconduct in clinical trials are selective reporting and the opportunistic use of the play of chance. Data fabrication and falsification were not rated highly because it was considered that these were unlikely to occur. Registration and publication of detailed clinical trial protocols could make an important contribution to preventing scientific misconduct.
NotesAl-Marzouki, Sanaa; Email Address: sanaa.al-marzouki@lshtm.ac.uk Roberts, Ian 1 Marshall, Tom 1 Evans, Stephen 1; Affiliation: 1: Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, 49-51 Bedford Square, London, WC1B 3DP, United Kingdom; Source Info: Jun2005, Vol. 26 Issue 3, p331; Subject Term: MEDICINE -- Research; Subject Term: CLINICAL trials; Subject Term: HUMAN experimentation in medicine; Subject Term: DELPHI method; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Delphi survey; Author-Supplied Keyword: Scientific misconduct; NAICS/Industry Codes: 541712 Reseach and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
DOI10.1016/j.cct.2005.01.011
Short TitleThe effect of scientific misconduct on the results of clinical trials: A Delphi survey
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