The improper use of research placebos

TitleThe improper use of research placebos
Publication TypeJournal Article
Year of Publication2010
AuthorsKottow, M
JournalJournal of Evaluation in Clinical Practice
Type of ArticleArticle
Publication Languageeng
ISSN Number13561294
Accession Number56600079
Keywordscomparative , Evidence , EVIDENCE-based , Human Research Subjects , MEDICINE , Moral , Placebos , RANDOMIZED , research
AbstractThis paper analyzes the use of placebos in phase III of clinical research and argues that reasons given for this practice are not ethically convincing. The author reviews his reasons for making this claim, and argues that that control groups should receive the best treatment in existence, not what is locally available nor a placebo. Inactive comparators should only be used when no effective medications exists for the disease under scrutiny. Bioethics should be wary of the tenuous justifications presented, as researchers rarely resort to placebos in their own sponsor countries, while actively endorsing them in Third World nations where most of their trials are being located.
NotesKottow, Miguel 1; Email Address:; Affiliation: 1: Full Professor, Universidad de Chile, Universidad Diego Portales, Santiago, Chile; Source Info: Dec2010, Vol. 16 Issue 6, p1041; Subject Term: PLACEBOS (Medicine); Subject Term: COMPARATIVE studies; Subject Term: RESEARCH -- Methodology; Subject Term: EVIDENCE-based medicine; Subject Term: RANDOMIZED controlled trials; Subject Term: MORAL & ethical aspects; Author-Supplied Keyword: evidence base medicine; Author-Supplied Keyword: evidence-based medical research; Author-Supplied Keyword: placebos; Author-Supplied Keyword: research ethics; Number of Pages: 4p; Document Type: Article
Short TitleThe improper use of research placebos
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