Comparing Drug Effectiveness at Health Plans: The Ethics of Cluster Randomized Trials

TitleComparing Drug Effectiveness at Health Plans: The Ethics of Cluster Randomized Trials
Publication TypeJournal Article
Year of Publication2008
AuthorsSabin, JE, Mazor, K, Meterko, V, Goff, SL, Platt, R
JournalHastings Center Report
Type of ArticleArticle
Publication Languageeng
ISSN Number00930334
Accession Number34590554
KeywordsClinical , Drugs , MEDICINE , Methodology , RANDOMIZED , research
AbstractThis article discusses a study which compares drug effectiveness under the conditions of actual use. There are several drawbacks of conventional randomized trials (CRTs), such as their results cannot be generated to the broad population and they do not offer information about performance under real-life conditions. In cluster randomized trials (CRTs), the research methodology provides a cost-effective approach to comparing the effectiveness of commonly used drugs in representative groups of individuals. It is concluded that CRTs of comparative drug effectiveness could be conducted at health plans without requiring individual informed consent.
NotesSABIN, JAMES E. MAZOR, KATHLEEN METERKO, VANESSA GOFF, SARAH L. PLATT, RICHARD; Source Info: Sep/Oct2008, Vol. 38 Issue 5, p39; Subject Term: DRUGS -- Effectiveness; Subject Term: RESEARCH; Subject Term: CLINICAL trials; Subject Term: METHODOLOGY; Subject Term: MEDICINE -- Research; Subject Term: RANDOMIZED controlled trials; NAICS/Industry Codes: 541712 Reseach and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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