The Impact of Unrealistic Optimism on Informed Consent in Early-Phase Oncology Trials

TitleThe Impact of Unrealistic Optimism on Informed Consent in Early-Phase Oncology Trials
Publication TypeJournal Article
Year of Publication2016
AuthorsJansen, LA, Mahadevan, D, Appelbaum, PS, Klein, WMP, Weinstein, ND, Mori, M, Daffe, R, Sulmasy, DP
JournalIRB: Ethics & Human Research
Date Published2016
Publication Languageeng
ISBN Number01937758
KeywordsCANCER , Clinical , Data , descriptive , FISHER , Informed , KRUSKAL-Wallis , MANN , OPTIMISM , PROBABILITY , Questionnaires , research , STATISTICS
AbstractThe article discusses the effect of exaggerated expectations for therapeutic benefit by patients enrolled in early-phase oncology trial. Topics include multicenter study on unrealistic optimism of oncology trial patients, used of Comparative Risk/Benefit Assessment Questionnaire (CRBA) model to assess the magnitude and prevalence of unrealistic optimism, and develop interventions to improve risk-benefit information awareness.
NotesJANSEN, LYNN A. 1 MAHADEVAN, DARUKA 2 APPELBAUM, PAUL S. 3,4,5 KLEIN, WILLIAM M. P. 6 WEINSTEIN, NEIL D. MORI, MOTOMI 7,8 DAFFE, RACKY 9 SULMASY, DANIEL P. 10,11; Affiliation: 1: Madeline Brill Nelson Chair in Ethics Education, Center for Ethics in Health Care, Oregon Health & Science University 2: Professor of medicine, University of Arizona director, Phase I Program, University of Arizona 3: Dollard Professor of Psychiatry, Medicine, & Law, Columbia University College of Physicians & Surgeons 4: Director, Division of Law, Ethics, and Psychiatry, Columbia University College of Physicians & Surgeons 5: Director, Center for Research on Ethical, Legal & Social Implications of Psychiatric, Neurologic & Behavioral Genetics, Department of Psychiatry, Columbia University College of Physicians & Surgeons 6: Associate director, Behavioral Research Program, National Cancer Institute, National Institutes of Health 7: Walter & Clora Brownfield Professor of Cancer Biostatistics, Oregon Health and Science University 8: Director, Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health and Science University 9: Senior research assistant, Oregon Health & Science University 10: Kilbride-Clinton Professor of Medicine, University of Chicago 11: Associate director, Divinity School, MacLean Center for Clinical Medical Ethics, University of Chicago; Source Info: Sep/Oct2016, Vol. 38 Issue 5, p1; Subject Term: Cancer patients; Subject Term: Clinical trials; Subject Term: Fisher exact test; Subject Term: Informed consent (Medical law); Subject Term: Optimism; Subject Term: Probability theory; Subject Term: Questionnaires; Subject Term: Research -- Finance; Subject Term: Statistics; Subject Term: Data analysis; Subject Term: Data analysis -- Software; Subject Term: Descriptive statistics; Subject Term: Mann Whitney U Test; Subject Term: Kruskal-Wallis Test; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article