Reproducibility Issues in Research with Animals and Animal Models

TitleReproducibility Issues in Research with Animals and Animal Models
Publication TypeReport
Year of Publication2015
AuthorsSciences, Eand Medici
Pagination8 p.
PublisherNational Academies Press
Place PublishedWashington, DC
Publication LanguageEnglish
AbstractScientific progress is achieved by robust experiments that generate reliable and reproducible results to be used with confidence by the research community. Recent publications have drawn attention to an apparent and concerning prevalence in the number of peer-reviewed studies that cannot be reproduced, particularly those containing data from experiments using animals and animal models. At this workshop1, researchers from around the world explored the many facets of animal-based research that could contribute to irreproducible results, including perspectives on improving experimental planning, design, and execution; the importance of reporting all methodological details; and efforts to establish harmonization principles of reporting on the care and use of animals in research studies. What follows is a factual summary of the presentations and discussions at the workshop.