Human-Animal Chimera: A Neuro Driven Discussion? Comparison of Three Leading European Research Countries

TitleHuman-Animal Chimera: A Neuro Driven Discussion? Comparison of Three Leading European Research Countries
Publication TypeJournal Article
Year of Publication2015
AuthorsTrujillo, LCabrera, Engel-Glatter, S
JournalScience & Engineering Ethics
Date Published2015
Publication Languageeng
ISBN Number13533452
KeywordsANIMAL , CHIMERISM , Human , HUMAN-animal , Moral , neural , neuroethics , Neurosciences , STEM
AbstractResearch with human-animal chimera raises a number of ethical concerns, especially when neural stem cells are transplanted into the brains of non-human primates (NHPs). Besides animal welfare concerns and ethical issues associated with the use of embryonic stem cells, the research is also regarded as controversial from the standpoint of NHPs developing cognitive or behavioural capabilities that are regarded as 'unique' to humans. However, scientists are urging to test new therapeutic approaches for neurological diseases in primate models as they better mimic human physiology than all current animal models. As a response, various countries have issued reports on the topic. Our paper summarizes the ethical issues raised by research with human-animal brain chimeras and compares the relevant regulatory instruments and different recommendations issued in national reports from three important European research nations: Germany, Switzerland and the United Kingdom. 
NotesCabrera Trujillo, Laura 1; Email Address: Engel-Glatter, Sabrina 1; Affiliation: 1: Institute of Biomedical Ethics, University of Basel, Bernoullistrasse 28 4056 Basel Switzerland; Source Info: Jun2015, Vol. 21 Issue 3, p595; Subject Term: HUMAN genetics; Subject Term: ANIMAL genetics; Subject Term: CHIMERISM; Subject Term: NEURAL stem cells -- Transplantation; Subject Term: ANIMAL welfare; Subject Term: NEUROSCIENCES -- Moral & ethical aspects; Author-Supplied Keyword: Human-animal chimera; Author-Supplied Keyword: Moral status; Author-Supplied Keyword: Neuroethics; Author-Supplied Keyword: Stem cells; Number of Pages: 23p; Document Type: Article