Both Sides of the Coin: Randomization from the Perspectives of Physician-Investigators and Patient-Subjects

TitleBoth Sides of the Coin: Randomization from the Perspectives of Physician-Investigators and Patient-Subjects
Publication TypeJournal Article
Year of Publication2010
AuthorsYap, TYi, Kassimatis, KA, Kodish, ED
JournalEthics & Behavior
Date Published2010
Publication Languageeng
ISBN Number10508422
KeywordsClinical , Conflict , DECISION , equipoise , etc. , ethics , Human , laws , Moral , OCCUPATIONAL , Patients , Physicians , randomization , research , SAMPLING
AbstractRandomization is the 'gold standard' design for clinical research trials and is accepted as the best way to reduce bias. Although some controversy remains over this matter, we believe equipoise is the fundamental ethical requirement for conducting a randomized clinical trial. Despite much attention to the ethics of randomization, the moral psychology of this study design has not been explored. This article analyzes the ethical tensions that arise from conducting these studies and examines the moral psychology of this design from the perspectives of physician-investigators and patient-subjects. 
NotesYap, Tsiao Yi 1 Kassimatis, Kathleen A. 2 Kodish, Eric D. 2; Affiliation: 1: Children's Hospital, Cleveland Clinic, 2: Department of Bioethics, Cleveland Clinic,; Source Info: Sep/Oct2010, Vol. 20 Issue 5, p380; Subject Term: CLINICAL trials; Subject Term: CONFLICT of interests; Subject Term: DECISION making; Subject Term: PATIENTS -- Legal status, laws, etc.; Subject Term: PHYSICIANS; Subject Term: RESEARCH -- Moral & ethical aspects; Subject Term: SAMPLING (Statistics); Subject Term: OCCUPATIONAL roles; Subject Term: RESEARCH personnel; Subject Term: RESEARCH subjects (Persons); Subject Term: ETHICS; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: equipoise; Author-Supplied Keyword: human subjects; Author-Supplied Keyword: moral psychology; Author-Supplied Keyword: randomization; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article