<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><rec-number>8765</rec-number><ref-type>Case Study </ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chowning, Jeanne Ting</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">National Center for Case Study Teaching in Science, University at Buffalo</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacogenetics : Using Genetics to Treat Disease</style></title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute</style></keyword><keyword><style  face="normal" font="default" size="100%">BIOETHICS</style></keyword><keyword><style  face="normal" font="default" size="100%">biomedical engineering</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug</style></keyword><keyword><style  face="normal" font="default" size="100%">GENETICS</style></keyword><keyword><style  face="normal" font="default" size="100%">MEDICINE</style></keyword><keyword><style  face="normal" font="default" size="100%">NURSING</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacogenetics;</style></keyword><keyword><style  face="normal" font="default" size="100%">PHARMACY</style></keyword><keyword><style  face="normal" font="default" size="100%">thiopurine</style></keyword><keyword><style  face="normal" font="default" size="100%">TPMT</style></keyword></keywords><taxonomies><taxonomy><style  face="normal" font="default" size="100%">Bioethics</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Pharmacy</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Nursing</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Genetics</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Medicine</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Biomedical Engineering </style></taxonomy></taxonomies><pubtype><style  face="normal" font="default" size="100%">Case Study </style></pubtype><audience-level><style  face="normal" font="default" size="100%">ug</style></audience-level><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">02/2010</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://sciencecases.lib.buffalo.edu/cs/collection/detail.asp?case_id=247&id=247</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">National Center for Case Study Teaching in Science, University at Buffalo</style></publisher><abstract><style face="normal" font="default" size="100%">This case study investigates the applications of genetics to medicine by exploring one of the first examples of a pharmacogenetic test to enter mainstream clinical practice. Pharmacogenetics examines how genetic variations in an individual correlate with responses to a specific medication in order to develop tailored medical treatments. Through a scenario based on clinical observations, students learn about acute lymphocytic leukemia as well as the wide range of individual responses to the drug used to treat it. Then, students interpret data similar to those initially published in scientific journals in order to construct an understanding of how genetic variation can be used to “tailor” medical care. Lastly, students are asked to apply their understanding of what they have learned in the case by making the appropriate medical recommendation based on a particular individual’s genotype.</style></abstract></record></records></xml>