<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><rec-number>6929</rec-number><ref-type>Journal Article</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hess, Pascale G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk of Tumorigenesis in First-in-Human Trials of Embryonic Stem Cell Neural Derivatives: Ethics in the Face of Long-Term Uncertainty</style></title><secondary-title><style face="normal" font="default" size="100%">Accountability in Research: Policies &amp; Quality Assurance</style></secondary-title><short-title><style face="normal" font="default" size="100%">Risk of Tumorigenesis in First-in-Human Trials of Embryonic Stem Cell Neural Derivatives: Ethics in the Face of Long-Term Uncertainty</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BIOLOGY</style></keyword><keyword><style  face="normal" font="default" size="100%">CARCINOGENESIS</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical</style></keyword><keyword><style  face="normal" font="default" size="100%">EMBRYONIC</style></keyword><keyword><style  face="normal" font="default" size="100%">etc.</style></keyword><keyword><style  face="normal" font="default" size="100%">ethics</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Human Research Subjects</style></keyword><keyword><style  face="normal" font="default" size="100%">Informed</style></keyword><keyword><style  face="normal" font="default" size="100%">Informed Consent</style></keyword><keyword><style  face="normal" font="default" size="100%">NERVOUS</style></keyword><keyword><style  face="normal" font="default" size="100%">neurodegenerative</style></keyword><keyword><style  face="normal" font="default" size="100%">RISK</style></keyword><keyword><style  face="normal" font="default" size="100%">RISK assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">SCIENCE</style></keyword><keyword><style  face="normal" font="default" size="100%">SPINAL</style></keyword><keyword><style  face="normal" font="default" size="100%">tissues</style></keyword><keyword><style  face="normal" font="default" size="100%">Transplantation</style></keyword></keywords><taxonomies><taxonomy><style  face="normal" font="default" size="100%">Risk Assessment</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Informed Consent</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Human Research Subjects</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Science </style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Biology</style></taxonomy></taxonomies><pubtype><style  face="normal" font="default" size="100%">Journal Article</style></pubtype><audience-level><style  face="normal" font="default" size="100%">ug</style></audience-level><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">175-198</style></pages><issn><style face="normal" font="default" size="100%">08989621</style></issn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">While the successful differentiation of human embryonic stem cells into high purity populations of specialized cells is viewed as a major step towards the safety of prospective human transplantation trials, concerns about the possible risks of tumor formation remain. These challenges are examined within the context of foreseen trials for disorders of the central nervous system. </style></abstract><doi><style face="normal" font="default" size="100%">10.1080/08989620903065145</style></doi><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><accession-num><style face="normal" font="default" size="100%">43211492</style></accession-num><notes><style face="normal" font="default" size="100%">HESS, PASCALE G. 1; Email Address: phess@ucla.edu; Affiliations: 1: Novel Tech Ethics, Dalhousie University, Halifax, Canada; Issue Info: Jul2009, Vol. 16 Issue 4, p175; Subject Term: TRANSPLANTATION of organs, tissues, etc. -- Risk factors; Subject Term: CLINICAL trials; Subject Term: NERVOUS system -- Degeneration; Subject Term: SPINAL cord -- Wounds &amp; injuries; Subject Term: EMBRYONIC stem cells; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: ethics; Author-Supplied Keyword: human embryonic stem cells; Author-Supplied Keyword: neurodegenerative diseases; Author-Supplied Keyword: spinal cord injury; Number of Pages: 24p; Document Type: Article</style></notes></record></records></xml>