<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><rec-number>5028</rec-number><ref-type>Journal Article</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jansen, Lynn A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Problem with Optimism in Clinical Trials</style></title><secondary-title><style face="normal" font="default" size="100%">IRB: Ethics &amp; Human Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinical</style></keyword><keyword><style  face="normal" font="default" size="100%">experimental</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Informed</style></keyword><keyword><style  face="normal" font="default" size="100%">Medical</style></keyword><keyword><style  face="normal" font="default" size="100%">MEDICINE</style></keyword></keywords><taxonomies><taxonomy><style  face="normal" font="default" size="100%">Human Research Subjects</style></taxonomy><taxonomy><style  face="normal" font="default" size="100%">Medicine</style></taxonomy></taxonomies><pubtype><style  face="normal" font="default" size="100%">Journal Article</style></pubtype><audience-level><style  face="normal" font="default" size="100%">ug</style></audience-level><dates><year><style  face="normal" font="default" size="100%">2006</style></year></dates><volume><style face="normal" font="default" size="100%">28</style></volume><pages><style face="normal" font="default" size="100%">13-19</style></pages><issn><style face="normal" font="default" size="100%">01937758</style></issn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The author reflects on the phenomenon of &quot;unrealistic optimism&quot; in clinical research compromising informed consent. She argues that its implications for the ethics of clinical research have not been fully appreciated and the phenomenon may be more difficult to address than either the therapeutic misconception or the therapeutic misestimation. She points out the lack of empirical research on the prevalence of unrealistic optimism in human subject clinical trials.</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><accession-num><style face="normal" font="default" size="100%">22043896</style></accession-num><notes><style face="normal" font="default" size="100%">Jansen, Lynn A.; Source Info: Jul/Aug2006, Vol. 28 Issue 4, p13; Subject Term: CLINICAL trials; Subject Term: HUMAN experimentation in medicine; Subject Term: MEDICAL ethics; Subject Term: MEDICINE -- Research; Subject Term: MEDICINE, Experimental; Subject Term: INFORMED consent (Medical law); NAICS/Industry Codes: 541712 Reseach and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article</style></notes></record></records></xml>