From Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between

TitleFrom Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between
Publication TypeCase Study
Year of Publication2013
AuthorsShaffer, JF
Corporate AuthorsUniversity at Buffalo, National Center for Case Study Teaching in Science,
Date Published05/2013
PublisherUniversity at Buffalo, National Center for Case Study Teaching in Science
KeywordsBIOCHEMISTRY , BIOETHICS , BIOLOGY , Biomedical , biomedical engineering , cell , Cell Biology , CHEMISTRY , MEDICINE , PHARMACY , PUBLIC , PUBLIC health , recombinant
AbstractBefore the discovery of insulin in 1921, being diagnosed with Type 1 diabetes was a death sentence. Despite the successful management of diabetes with purified animal insulin, potentially severe side effects were abundant, and alternative ways to produce insulin were needed. This case study guides students through the history of using insulin to treat diabetes, focusing on the development of recombinant DNA technology and the world's first bioengineered drug, recombinant human insulin, which is now used worldwide to treat diabetes. Through the course of this case, students consider the central dogma of molecular biology, the development of recombinant DNA technology, drug design, the importance of recombinant proteins to our society, and the ethical analysis and debates that occur as a result of some scientific discoveries. This case was developed as an introduction to an upper-division biotechnology course focusing on recombinant protein design and production, but could also be used in molecular biology, biochemistry, or introductory biology courses to highlight recombinant DNA and biotechnology.
URLhttp://sciencecases.lib.buffalo.edu/cs/collection/detail.asp?case_id=684&id=684
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