The Chemistry of Cooley's Anemia

TitleThe Chemistry of Cooley's Anemia
Publication TypeCase Study
Year of Publication2003
AuthorsBailey, CT, Mahroof-Tahir, M
Corporate AuthorsNational Center for Case Study Teaching in Science, University at Buffalo,
Date Published03/2003
PublisherNational Center for Case Study Teaching in Science, University at Buffalo
KeywordsBIOCHEMISTRY , BIOETHICS , BIOLOGY , chelation , CHEMISTRY , Cooley's , coordination , deferoxamine , Desferal , Genetic , hemoglobin , Iron , metal , THALASSEMIA
AbstractYoung parents, Max and Andrea Forest, learn that their child is suffering from the genetic disorder, thalassemia. Treatment requires a lifetime commitment to whole blood transfusion and chelation therapy, both of which must be administered on a daily to weekly basis. Students read the case, answer a series of questions, and then decide how they would treat the child if they were the parents. The case was developed to introduce students to the role of metal ions and coordination chemistry in biological systems. It would be appropriate for use in courses in biochemistry, molecular biology, bioinorganic chemistry, and bioethics, among others.
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