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Toward correlation in in vivo and in vitro nanotoxicology studies.

By csep - Posted on 22 February 2013

TitleToward correlation in in vivo and in vitro nanotoxicology studies.
Publication TypeJournal Article
Year of Publication2012
AuthorsMaurer-Jones, Melissa A., and Haynes Christy L.
JournalThe Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
Date Published2012 Winter
Publication Languageeng
ISSN Number1748-720X
KeywordsToxicological Studies

Nanomaterials have the promise of revolutionizing current treatment and diagnosis of diseases, which has led to 33 nanotherapeutics drugs currently on the market and many more in various stages of clinical trials. With an increasing number of products available and in development, along with the unique, emergent properties of the nanoparticle therapeutics themselves, regulatory agencies are now faced with decisions regarding the regulation of such novel technologies. Regulatory guidance, particularly in pre-clinical stages, has the potential to facilitate quick and safe development of these novel materials, but new regulation beyond what is currently in place must be justified in a clear and distinctive toxic response. Herein, we examine literature that compares and correlates in vivo and in vitro nanotoxicity studies to gain a deeper understanding of the modes of nanoparticle toxicity. Additionally, this comparison aims to identify clear and unique toxicity responses caused by nanoparticles, which informs our perspective on pre-clinical nanotherapeutic oversight.

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Alternate JournalJ Law Med Ethics

38 Die in Mental Hospital Fire Outside Moscow


A fire swept quickly through a psychiatric hospital outside Moscow early Friday, killing 38 people, most of them sedated and in their beds, officials said.
The one-story brick-and-wood hospital building housed patients with severe mental disorders, Health Ministry officials said. An Emergencies Ministry official said the fire started in a wooden annex and then spread to the main brick building, which had wooden beams.
The patients were under sedatives and most of them did not wake up, Yuri Deshevykh of the Emergencies Ministry told RIA Novosti.
At least 29 people were burned alive, said Irina Gumennaya, a spokeswoman for the federal Investigative Committee.
Investigators said the 38 dead included 36 patients and two doctors. They said a nurse managed to escape and save one patient, while another patient got out on his own. The Emergencies Ministry also posted a list of the patients indicating they ranged in age from 20 to 76. Gumennaya told Russian news agencies that most of the people died in their beds.


Moscow region Governor Andrei Vorobyev said some of the hospital windows were barred. Gumennaya cited the surviving nurse as saying that the doors inside the hospital were not locked.
Investigators said they are looking at violations of fire regulations and a short circuit as possible causes for the blaze that engulfed the hospital in the Ramensky settlement,Pullip, some 85 kilometers (53 miles) north of Moscow.
Vadim Belovoshin of the Emergencies Ministry said that it took firefighters an hour to get to the hospital because a ferry across a canal was closed and they had to make a detour.
Vorobyev told Russian state television that the fire alarm seems to have worked, but the fire spread too quickly.
Russia has a poor fire safety record, with about 12,000 deaths reported in 2012. In January, a fire in an underground parking lot killed 10 migrant workers from Tajikistan who were working and living there. In a similar incident in September, 14 Vietnamese workers were killed by fire at a clothing factory near Moscow.
In one of the most high-profile cases of negligence, more than 150 people died in a night club in the city of Perm after a pyrotechnic show ignited a wooden ceiling.