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In vivo biodistribution and toxicity depends on nanomaterial composition, size, surface functionalisation and route of exposure


By csep - Posted on 04 June 2010

Title In vivo biodistribution and toxicity depends on nanomaterial composition, size, surface functionalisation and route of exposure
Publication TypeJournal Article
Year of Publication2008
AuthorsHarper, S. C., Usenko C., Maddux B. L. S., and Tanguay R. L.
JournalJournal of Experimental Nanoscience
Volume3
Start Page196
Issue3
Pagination195-206
Date Published09/2008
Publication LanguageEnglish
ISSN Number1745-8080
Abstract

In this study, researchers subjected embryonic zebrafish to a wide variety of manufactured nanomaterials to test how chemical composition, size, surface functionalisation, and route of exposure on nanomaterial-biological interactions to see what kinds of nanomaterials are bioactive, and which are not. The results of this show that this model of testing is an effective model to assess the biological activity and toxic potential of nanomaterials in a short period of time with minimal cost.