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Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung; Important Implications for Nanoparticle Testing.


By csep - Posted on 18 November 2010

TitleMetal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung; Important Implications for Nanoparticle Testing.
Publication TypeJournal Article
Year of Publication2010
AuthorsCho, Wan-Seob, Duffin Rodger, Poland Craig A., Howie Sarah E. M., Macnee William, Bradley Mark, Megson Ian L., and Donaldson Ken
JournalEnvironmental health perspectives
Date Published2010 Aug 20
Publication Languageeng
Abstract

BACKGROUND: Metal oxide nanoparticles (NP) have been widely used in industry, cosmetics, and biomedicine. OBJECTIVES: High NP production volumes raise concerns for occupational exposure via inhalation, necessitating hazard evaluation. The researchers exposed the lungs of rats to a panel of well-characterized NP (CeO2NP, TiO2NP, CBNP, SiO2NP, NiONP, ZnONP, CuONP, and Beads) and evaluated the inflammation potency was evaluated at 24 h and 4 wks post-instillation. For NP that caused significant inflammation at 24 h, they then investigated the characteristics of the inflammation. All exposures were carried out at equal surface area dose. They found that only CeO2NP, NiONP, ZnONP, and CuONP were inflammogenic to the lungs of rats at the high doses used. The researchers concluded that different types of inflammation imply different hazards in terms of pathology, risks and risk severity. In vitro testing could not have differentiated these complex hazard outcomes and this has important implications for the global strategy for NP hazard assessment. They conclude that their results demonstrate that NP cannot be viewed as a single hazard entity and that risk assessment should be performed separately and with caution for different NP.

DOI10.1289/ehp.1002201
Source Web Site

http://www.ncbi.nlm.nih.gov/pubmed/20729176?dopt=Abstract