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Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology


By csep - Posted on 01 September 2010

TitleSafety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
Publication TypeJournal Article
Year of Publication2010
AuthorsOberdörster, G.
JournalJournal of Internal Medicine
Volume267
Issue1
Pagination89 - 105
Date Published01/2010
Abstract

This article discusses the difficulty of accessing the toxicity of engineered nanoparticles, and points out that studies that use only extraordinary high doses must be interpreted with caution. The author discusses key concepts of nanotoxicity, such as the significance of dose, dose rate, and biokinetics, and discussing the importance of detailed physico-chemical characterization of nanoparticles, especially surface properties. The author uses the example of multi-walled carbon nanotubes to illustrate the difficulty of extrapolating toxicological results from current tests being done.

DOI10.1111/j.1365-2796.2009.02187.x